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Lose here and the save file goes with you, no exceptions and no second chance. FTL: Faster Than Light and Spelunky 2 both build entire runs around that risk, Don't Starve turns every single winter into a real threat to plan around, and NEO Scavenger can end a run over one wrong item choice made in a hurry. A single mistake ends the run in every one of these, roguelike or survival sim alike.

One death and the run is over - 126 games